SRP-HM40B-100μg / 询价
SRP-HM40B-500μg / 询价
SRP-HM40B-500μgx2 / 询价
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Human SIRP Beta/CD172b Protein
Recombinant Human SIRP Beta/CD172b Protein is expressed from HEK293 with His tag and Avi tag at the C-Terminus.It contains Glu30-Ala369 [Accession | O00241-1].
The protein has a predicted MW of 40 kDa. Due to glycosylation, the protein migrates to 52-60 kDa based on Bis-Tris PAGE result.
> 95% as determined by Bis-Tris PAGE
> 95% as determined by HPLC
Less than 1EU per μg by the LAL method.
Lyophilized from 0.22μm filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
-20 to -80°C for 12 months as supplied from date of receipt.
-80°C for 3 months after reconstitution.
Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Human SIRP Beta on Bis-Tris PAGE under reduced conditions. The purity is greater than 95%.
The purity of Human SIRP Beta is greater than 95% as determined by SEC-HPLC.
SIRP beta 1 is a type I transmembrane protein belonging to the SIRP family within the Ig superfamily. Members of this family are characterized by an extracellular region containing a V-set Ig domain containing a J-like sequence and two C1-set Ig domains.SIRP beta 1 is immunoglobulin-like cell surface receptor involved in the negative regulation of receptor tyrosine kinase-coupled signaling processes. Participates also in the recruitment of tyrosine kinase SYK. Triggers activation of myeloid cells when associated with TYROBP.
SIRP-beta-1 isoform 3; SIRPB1; CD172b; DKFZp686A05192; FLJ26614; 9930027N05Rik; SIRP-beta; Sirpb; Sirpb1; Sirpb1a;SIRP-β-1 isoform 3; SIRP-β
(1)Takizawa H , Manz M G. Macrophage tolerance: CD47–SIRP-α–mediated signals matter[J]. Nature Immunology, 2007, 8(12):1287-1289.
