货号价格

SRP-HM40B-100μg / 询价

SRP-HM40B-500μg / 询价

SRP-HM40B-1mg / 询价

Human SIRP Beta/CD172b Protein

产品信息(Product Info)
表达区间及表达系统(Source)

Recombinant Human SIRP Beta/CD172b Protein is expressed from Expi293 with His tag and Avi tag at the C-terminal. It contains Glu30-Ala369.[Accession | O00241-1]

分子量大小(Molecular Weight)

The protein has a predicted MW of 40 kDa. Due to glycosylation, the protein migrates to 52-60 kDa based on Tris-Bis PAGE result.

内毒素(Endotoxin)

Less than 1EU per μg by the LAL method.

纯度(Purity)

> 95% as determined by Tris-Bis PAGE
> 95% as determined by HPLC

制剂(Formulation)

Lyophilized from 0.22μm filtered solution in PBS (pH 7.4). Normally 5% trehalose is added as protectant before lyophilization.

重构方法(Reconstitution)

Centrifuge tubes before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.

存储(Storage)

-20 to -80°C for 12 months as supplied from date of receipt.
-20 to -80°C for 3-6 months in unopened state after reconstitution.
2-8°C for 2-7 days after reconstitution.
Recommend to aliquot the protein into smaller quantities for optimal storage. Please avoid freeze-thaw cycles.

产品数据(Assay Data)
Tris-Bis PAGE

Human SIRP Beta on Tris-Bis PAGE under reduced conditions. The purity is greater than 95%.

SEC-HPLC

The purity of Human SIRP Beta is greater than 95% as determined by SEC-HPLC.

背景(Background)

SIRP beta 1 is a type I transmembrane protein belonging to the SIRP family within the Ig superfamily. Members of this family are characterized by an extracellular region containing a V-set Ig domain containing a J-like sequence and two C1-set Ig domains.SIRP beta 1 is immunoglobulin-like cell surface receptor involved in the negative regulation of receptor tyrosine kinase-coupled signaling processes. Participates also in the recruitment of tyrosine kinase SYK. Triggers activation of myeloid cells when associated with TYROBP.

分子别名(Synonyms)

SIRP-beta-1 isoform 3; SIRPB1; CD172b; DKFZp686A05192; FLJ26614; 9930027N05Rik; SIRP-beta; Sirpb; Sirpb1; Sirpb1a;SIRP-β-1 isoform 3; SIRP-β

文献(References)

(1)Takizawa H , Manz M G. Macrophage tolerance: CD47–SIRP-α–mediated signals matter[J]. Nature Immunology, 2007, 8(12):1287-1289.

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