ST2-HM2L1-100μg / 询价
ST2-HM2L1-500μg / 询价
ST2-HM2L1-500μgx2 / 询价
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Human IL-1RL1/sST2/ST2S Protein
Recombinant Human IL-1RL1/ST2 Protein is expressed from HEK293 with hFc (IgG1) tag at the C-terminus.It contains Lys19-Phe328 [Accession | Q01638-2].
The protein has a predicted MW of 61.75 kDa. Due to glycosylation, the protein migrates to 75-100 kDa based on Bis-Tris PAGE result.
> 95% as determined by Bis-Tris PAGE
> 90% as determined by HPLC
Less than 1 EU per μg by the LAL method.
Lyophilized from 0.22 μm filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Dissolve the lyophilized protein in distilled water. Please refer to the Certificate of Analysis for detailed instructions.
-20 to -80°C for 12 months as supplied from date of receipt.
-80°C for 3 months after reconstitution.
Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
IL1RL1(also known as ST2) is a member of the IL1 receptor family and serves as the receptor for IL-33. The ST2 protein has two isoforms including sST2 and the membrane-bound ST2 receptor, referred to as ST2L. Preclinical studies have demonstrated that binding of IL-33 to ST2L elicits a cardioprotective effect. ST2/IL-33 signaling may play an important role in intestinal disease.
IL1RL1; DER4; ST2; T1; FIT-1; IL33R; ST2L; ST2V; IL-1 R4; IL1R4; Ly84; MGC32623
[1] Griesenauer B, Paczesny S. The ST2/IL-33 Axis in Immune Cells during Inflammatory Diseases. Front Immunol. 2017 Apr 24;8:475.
[2] Vianello E, Dozio E, Tacchini L, Frati L, Corsi Romanelli MM. ST2/IL-33 signaling in cardiac fibrosis. Int J Biochem Cell Biol. 2019 Nov;116:105619.
[3] Dattagupta A, Immaneni S. ST2: Current status. Indian Heart J. 2018 Jul;70 Suppl 1(Suppl 1):S96-S101.
