XCT-HM10NB-100μg / 询价
XCT-HM10NB-100μgx5 / 询价
XCT-HM10NB-100μgx10 / 询价
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Biotinylated Human Cystine/glutamate transporter (SLC7A11) Nanodisc
Recombinant Biotinylated Human Cystine/glutamate transporter (SLC7A11) Nanodisc is expressed from HEK293 with His tag at the C-terminus.It contains Met1-Leu501 [Accession | Q9UPY5].
The protein has a predicted MW of 68.4 kDa.
Less than 1 EU per μg by the LAL method.
Supplied as 0.22 μm filtered solution in PBS, 200mM L-Arginine (pH 7.4). Notice: Not recommended for flow cytometry in mammalian cells.
Valid for 6 months from date of receipt when stored at -80°C.
Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Immobilized Biotinylated Human SLC7A11 Nanodisc, His Tag at 5μg/ml (100μl/well) on the streptavidin precoated plate (5μg/ml). Dose response curve for Anti-SLC7A11 Antibody, hFc Tag with the EC50 of 59.3ng/ml determined by ELISA (QC Test). (QC Test)
Biotinylated Human SLC7A11 Nanodisc, His Tag captured on CM5 Chip via Streptavidin can bind Anti-SLC7A11 Antibody, hFc Tag with an affinity constant of 1.55 nM as determined in SPR assay (Biacore T200).
Solute Carrier Family 7 Member 11 (SLC7A11, also known as xCT) is the functional subunit of the Xc- system, an anionic L-cystine/L-glutamate antiporter expressed on the cell surface. SLC7A11 expression is significantly upregulated in several types of cancers in which it can inhibit ferroptosis and favor cancer cell proliferation, invasion and chemoresistance. SLC7A11 expression is also increased in ovarian cancer tissues, suggesting a possible role of this protein as a therapeutic target.
Cystine/glutamate transporter; xCT; SLC7A11; CCBR1;
Fantone S, Piani F, Olivieri F, Rippo MR, Sirico A, Di Simone N, Marzioni D, Tossetta G. Role of SLC7A11/xCT in Ovarian Cancer. Int J Mol Sci. 2024 Jan 2;25(1):587. doi: 10.3390/ijms25010587. PMID: 38203758; PMCID: PMC10779187.
