DLL-HM103B-100μg / 询价
DLL-HM103B-500μg / 询价
DLL-HM103B-500μgx2 / 询价
- 关联产品
- 客服电话
- 技术支持
Biotinylated Human DLL3 Protein (Primary Amine Labeling)
Recombinant Biotinylated Human DLL3 Protein (Primary Amine Labeling) is expressed from HEK293 with His tag at the N-Terminus It contains Ala27-Arg490 [Accession | Q9NYJ7-1].
The protein has a predicted MW of 50.4 kDa. Due to glycosylation, the protein migrates to 52-60 kDa based on Bis-Tris PAGE result.
> 95% as determined by Bis-Tris PAGE
Less than 1 EU per ug by the LAL method.
Lyophilized from 0.22 μm filtered solution in PBS, 200 mM L-Arginine (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Dissolve the lyophilized protein in distilled water. Please refer to the Certificate of Analysis for detailed instructions.
-20 to -80°C for 12 months as supplied from date of receipt.
-80°C for 3 months after reconstitution.
Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Biotinylated Human DLL3 on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.
Immobilized Biotinylated Human DLL3, His Tag at 0.5μg/ml (100μl/well) on the streptavidin precoated plate (5μg/ml). Dose response curve for Anti-DLL3 Antibody, hFc Tag with the EC50 of 3.1ng/ml determined by ELISA (QC Test).
Loaded Anti-DLL3 Antibody, hFc Tag on ProA-Biosensor can bind Biotinylated Human DLL3, His Tag with an affinity constant of 0.27 nM as determined in BLI assay (Gator® Prime).
Delta-like protein 3 (DLL3) is a transmembrane protein that belongs to the Delta/Serrate/Lag-2 (DSL) family of Notch ligands. DLL3 inhibits primary neurogenesis. May be required to divert neurons along a specific differentiation pathway. Plays a role in the formation of somite boundaries during segmentation of the paraxial mesoderm (By similarity).
Delta3; DLL3; Pudgy; SCDO1; SCDO1delta3
Saunders L R , Bankovich A J , Anderson W C , et al. A DLL3-targeted antibody-drug conjugate eradicates high-grade pulmonary neuroendocrine tumor-initiating cells in vivo[J]. Science Translational Medicine, 2015.
