DR3-HM603-100μg / 询价
DR3-HM603-500μg / 询价
DR3-HM603-500μgx2 / 询价
Human DR3/TNFRSF25 Protein
Recombinant Human DR3/TNFRSF25 Protein is expressed from HEK293 with His tag and hFc tag at the C-terminus.It contains Gln25-Gln199 [Accession | AAI17190].
The protein has a predicted MW of 49.80 kDa. Due to glycosylation, the protein migrates to 60-70 kDa based on Bis-Tris PAGE result.
>95% as determined by Bis-Tris PAGE
Less than 1 EU per μg by the LAL method.
Supplied as 0.22 μm filtered solution in PBS (pH 7.4).
Valid for 12 months from date of receipt when stored at -80°C.
Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Human DR3 on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.
Immobilized Human TNFSF15 Trimer, His Tag at 2μg/ml (100μl/well) on the plate. Dose response curve for Human DR3, hFc Tag with the EC50 of 0.67μg/ml determined by ELISA (QC Test).
Human DR3, hFc Tag captured on CM5 Chip via Protein A can bind Human TNFSF15 Trimer, His Tag with an affinity constant of 0.10 nM as determined in SPR assay (Biacore T200).
Death Receptor 3 (DR3), also known as TNFRSF25, TRAMP, LARD, or WSL-1, is a death-domain-containing TNF-family receptor that, like its closest paralog TNFR1, binds the adaptor molecule TRADD through its cytoplasmic death domain. TRADD recruitment endows DR3 with dual-signaling capability to activate NF−κB and MAP-kinase signaling or alternatively trigger caspase activation and programmed cell death.
APO3; DDR3; DR3; TNFRSF12; WSL; WSL1; TNFRSF25; LARD; TR3; TRAMP; WSL-LR
Meylan F, Davidson TS, Kahle E, Kinder M, Acharya K, Jankovic D, Bundoc V, Hodges M, Shevach EM, Keane-Myers A, Wang EC, Siegel RM. The TNF-family receptor DR3 is essential for diverse T cell-mediated inflammatory diseases. Immunity. 2008 Jul 18;29(1):79-89. doi: 10.1016/j.immuni.2008.04.021. Epub 2008 Jun 19. PMID: 18571443; PMCID: PMC2760084.
