IL1-MM1R1-100μg / 询价
IL1-MM1R1-500μg / 询价
IL1-MM1R1-500μgx2 / 询价
Mouse IL-1R1 Protein
Recombinant Mouse IL-1R1 Protein is expressed from HEK293 with His tag at the C-Terminus. It contains Leu20-Lys338.[Accession | P13504-1]
The protein has a predicted MW of 38.4 kDa. Due to glycosylation, the protein migrates to 50-70 kDa based on Tris-Bis PAGE result.
Less than 1EU per μg by the LAL method.
> 95% as determined by Tris-Bis PAGE
> 95% as determined by HPLC
Lyophilized from 0.22μm filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
-20 to -80°C for 12 months as supplied from date of receipt.
-80°C for 3-6 months after reconstitution.
2-8°C for 2-7 days after reconstitution.
Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Mouse IL-1R1 on Tris-Bis PAGE under reduced condition. The purity is greater than 95%.
The purity of Mouse IL-1R1 is greater than 95% as determined by SEC-HPLC.
Mouse IL-1R1, His Tag immobilized on CM5 Chip can bind Mouse IL-1 alpha, His Tag with an affinity constant of 51.22 nM as determined in SPR assay (Biacore T200).
Interleukin 1 (IL-1) has long been known for its pleiotropic effects on inflammation that plays a complex, and sometimes contrasting, role in different stages of cancer development.IL-1R1 is the main receptor for both ligands and is expressed by various cell types, including innate and adaptive immune cell types, epithelial cells, endothelial cells, adipocytes, chondrocytes, fibroblasts, etc. IL-1 and IL-1R1 receptor interaction leads to a set of common signaling pathways, mainly the NF-kB and MAP kinase pathways, as a result of complex positive and negative regulations.
IL-1R-1; IL-1RT1; IL-1R-alpha; CD121a; IL-1 RI; IL1R; IL1RI; IL-1RI; p80; D2S1473; IL1RA
(1) Zhang W, Borcherding N, Kolb R. IL-1 Signaling in Tumor Microenvironment. Adv Exp Med Biol. 2020;1240:1-23. doi: 10.1007/978-3-030-38315-2_1. PMID: 32060884.
