IL2-HM220 | 价格

IL2-HM220-100μg / 询价

IL2-HM220-500μg / 询价

IL2-HM220-500μgx2 / 询价

Human IL-20 Protein

产品信息(Product Info)
表达区间及表达系统(Source)

Recombinant Human IL-20 Protein is expressed from HEK293 with His tag at the N-Terminus.
It contains Leu25-Leu176 [Accession | Q9NYY1-1].

分子量大小(Molecular Weight)

The protein has a predicted MW of 19.4 kDa. Due to glycosylation, the protein migrates to 20-25 kDa based on Bis-Tris PAGE result.

纯度(Purity)

> 95% as determined by Bis-Tris PAGE
> 95% as determined by HPLC

内毒素(Endotoxin)

Less than 1EU per μg by the LAL method.

制剂(Formulation)

Lyophilized from 0.22μm filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.

重构方法(Reconstitution)

Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.

存储(Storage)

-20 to -80°C for 12 months as supplied from date of receipt.
-80°C for 3 months after reconstitution.
Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.

产品数据(Assay Data)
Bis-Tris PAGE

Human IL-20 on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.

SEC-HPLC

The purity of Human IL-20 is greater than 95% as determined by SEC-HPLC.

背景(Background)

Interleukin (IL)-20 is a member of the IL-10 family of cytokines, which has been reported to participate in autoimmune inflammatory diseases. However, the potential role of IL-20 in hepatocellular carcinoma (HCC) progression has not yet been investigated. In addition, IL-20 expression was significantly associated with tumor size, metastasis, TNM stage and poor prognosis in patients with HCC.

分子别名(Synonyms)

IL-20; Cytokine Zcyto10; Zcyto10; IL10D; MGC96907

文献(References)

(1) Ding WZ, Han GY, Jin HH, Zhan CF, Ji Y, Huang XL. Anti-IL-20 monoclonal antibody suppresses hepatocellular carcinoma progression. Oncol Lett. 2018 Nov;16(5):6156-6162. doi: 10.3892/ol.2018.9402. Epub 2018 Sep 5. PMID: 30333881; PMCID: PMC6176420.

Note: HPLC results always come from liquid protein, due to absorption peak interference of trehalose in lyophilized powder.