IL7-MM2RA-100μg / 询价
IL7-MM2RA-500μg / 询价
IL7-MM2RA-500μgx2 / 询价
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Mouse IL-7 R alpha/CD127 Protein
Recombinant Mouse IL-7 R alpha/CD127 Protein is expressed from HEK293 with hFc tag at the C-Terminus.It contains Glu21-Asp239 [Accession | NP_032398.3].
The protein has a predicted MW of 51.74 kDa. Due to glycosylation, the protein migrates to 60-70 kDa based on Bis-Tris PAGE result.
> 95% as determined by Bis-Tris PAGE
> 95% as determined by HPLC
Less than 1EU per μg by the LAL method.
Lyophilized from 0.22μm filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
-20 to -80°C for 24 months as supplied from date of receipt.
-80°C for 3 months after reconstitution.
Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Mouse IL-7 R alpha on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.
The purity of Mouse IL-7 R alpha is greater than 95% as determined by SEC-HPLC.
Immobilized Human IL-7, No Tag at 2μg/ml (100μl/well) on the plate. Dose response curve for Mouse IL-7 R alpha, hFc Tag with the EC50 of 10.4ng/ml determined by ELISA (QC Test).
Interleukin 7 (IL-7) and its receptor (IL-7R, a heterodimer of IL-7Rα and γc) are essential for normal lymphoid development. IL-7 and IL-7R activate three main pathways: STAT5, PI3K/Akt/mTOR and MEK/Erk, ultimately leading to the promotion of leukemia cell viability, cell cycle progression and growth.
IL-7R alpha; IL7Ra; CD127; CDW127; ILRA
(1)Oliveira ML, Akkapeddi P, Ribeiro D, Melão A, Barata JT. IL-7R-mediated signaling in T-cell acute lymphoblastic leukemia: An update. Adv Biol Regul. 2019 Jan;71:88-96. doi: 10.1016/j.jbior.2018.09.012. Epub 2018 Sep 19. PMID: 30249539; PMCID: PMC6386770.
