LRP-HM316-100μg / 询价
LRP-HM316-500μg / 询价
LRP-HM316-500μgx2 / 询价
Human LRP-6 Protein
Recombinant Human LRP-6 Protein is expressed from HEK293 with mFc (IgG2a) tag at the C-terminus.It contains Ala20-Pro630 [Accession | O75581-1].
The protein has a predicted MW of 95.32 kDa. Due to glycosylation, the protein migrates to 97-110 kDa based on Bis-Tris PAGE result.
> 90% as determined by Bis-Tris PAGE
Less than 1 EU per μg by the LAL method.
Supplied as 0.22 μm filtered solution in PBS (pH 7.4).
Valid for 12 months from date of receipt when stored at -80°C.
Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Human LRP-6 on Bis-Tris PAGE under reduced condition. The purity is greater than 90%.
Immobilized Human DKK1, His Tag at 5μg/ml (100μl/well) on the plate. Dose response curve for Human LRP-6, mFc Tag with the EC50 of 1.03μg/ml determined by ELISA (QC Test).
Immobilized Human SOST, His Tag at 2μg/ml (100μl/well) on the plate. Dose response curve for Human LRP-6, mFc Tag with the EC50 of 13.1ng/ml determined by ELISA.
Immobilized Human LRP-6, mFc Tag at 5μg/ml (100μl/well) on the plate. Dose response curve for Human R spondin 1, His Tag with the EC50 of 4.4μg/ml determined by ELISA.
Low-density lipoprotein receptor protein 6 (LRP6) is a Wnt co-receptor with essential functions in the Wnt/β-catenin pathway, and mutations in LRP6 gene are linked to many complex human diseases, including metabolic syndrome, cancer, Alzheimer's disease and osteoporosis. LRP-6 interacts closely with PDGF receptor β and TGF-β receptor 1 at the cell membrane, suggesting that it may have roles in pathways other than WNT/β-catenin.
LRP-6; DCAD2; FLJ90062; FLJ90421;LRP6
(1) Ren S, Johnson BG, Kida Y, Ip C, Davidson KC, Lin SL, Kobayashi A, Lang RA, Hadjantonakis AK, Moon RT, Duffield JS. LRP-6 is a coreceptor for multiple fibrogenic signaling pathways in pericytes and myofibroblasts that are inhibited by DKK-1. Proc Natl Acad Sci U S A. 2013 Jan 22;110(4):1440-5. doi: 10.1073/pnas.1211179110. Epub 2013 Jan 9. Erratum in: Proc Natl Acad Sci U S A. 2016 Nov 14;: PMID: 23302695; PMCID: PMC3557093.
(2) Wang ZM, Luo JQ, Xu LY, Zhou HH, Zhang W. Harnessing low-density lipoprotein receptor protein 6 (LRP6) genetic variation and Wnt signaling for innovative diagnostics in complex diseases. Pharmacogenomics J. 2018 May 22;18(3):351-358. doi: 10.1038/tpj.2017.28. Epub 2017 Jul 11. PMID: 28696417.
