TSP-HM401-100μg / 询价
TSP-HM401-500μg / 询价
TSP-HM401-500μgx2 / 询价
Human TSLP Protein
Recombinant Human TSLP Protein is expressed from HEK293 with His tag and Avi tag at the C-Terminus.It contains Tyr29-Gln159 [Accession | Q969D9-1].
The protein has a predicted MW of 17.8 kDa. Due to furin cleavage site, the protein migrates to 12 kDa&20-25 kDa based on Bis-Tris PAGE result.
> 95% as determined by Bis-Tris PAGE
> 95% as determined by HPLC
Less than 1EU per μg by the LAL method.
Lyophilized from 0.22μm filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
-20 to -80°C for 12 months as supplied from date of receipt.
-80°C for 3 months after reconstitution.
Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Human TSLP on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.
The purity of Human TSLP is greater than 95% as determined by SEC-HPLC.
Immobilized Human TSLP, His Tag at 5μg/ml (100μl/well) on the plate. Dose response curve for Human TSLPR, hFc Tag with the EC50 of 50.8ng/ml determined by ELISA (QC Test).
Immobilized Human TSLP, His Tag at 1μg/ml (100μl/well) on the plate. Dose response curve for Anti-TSLP Antibody, hFc Tag with the EC50 of 13.0ng/ml determined by ELISA.
Human TSLP, His Tag captured on CM5 Chip via Anti-His Antibody can bind Human TSLPR, hFc Tag with an affinity constant of 1.04 nM as determined in SPR assay (Biacore T200).
Thymic Stromal Lymphopoietin (TSLP) was originally identified as an activity from the conditioned medium of a mouse thymic stromal cell line that promoted the development of B cells. Cytokine that induces the release of T-cell-attracting chemokines from monocytes and, in particular, enhances the maturation of CD11c dendritic cells. Can induce allergic inflammation by directly activating mast cells.
thymic stromal lymphopoietin; TSLP
(1)Corren J , Parnes J R , Wang L , et al. Tezepelumab in Adults with Uncontrolled Asthma[J]. New England Journal of Medicine, 2017, 377(10):936-946.
