ITG-HM1V6-100μg / 询价
ITG-HM1V6-500μg / 询价
ITG-HM1V6-500μgx2 / 询价
表达区间及表达系统(Source)
|
Recombinant Mouse&Human Chimeric Integrin alpha V beta 6 (ITGAV&ITGB6) Heterodimer Protein is expressed from HEK293 with His tag at the C-terminus.It contains Phe31-Val988 (ITGAV) acidic tail and Gly22-Asn707 (ITGB6) basic tail [Accession | P43406(ITGAV)&P18564-1(ITGB6)]. |
分子量大小(Molecular Weight)
|
The protein has a predicted MW of 131.48 kDa (ITGAV) and 79.1 kDa (ITGB6). Due to glycosylation, the protein migrates to 120-160 kDa (ITGAV) and 90-120 kDa (ITGB6) based on Bis-Tris PAGE result. |
纯度(Purity)
|
> 95% as determined by Bis-Tris PAGE |
内毒素(Endotoxin)
|
Less than 1EU per μg by the LAL method. |
制剂(Formulation)
|
Lyophilized from 0.22 μm filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization. |
重构方法(Reconstitution)
|
Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water. |
存储(Storage)
|
-20 to -80°C for 12 months as supplied from date of receipt. |
Recombinant Mouse&Human Chimeric Integrin alpha V beta 6 (ITGAV&ITGB6) Heterodimer Protein is expressed from HEK293 with His tag at the C-terminus.It contains Phe31-Val988 (ITGAV) acidic tail and Gly22-Asn707 (ITGB6) basic tail [Accession | P43406(ITGAV)&P18564-1(ITGB6)].
The protein has a predicted MW of 131.48 kDa (ITGAV) and 79.1 kDa (ITGB6). Due to glycosylation, the protein migrates to 120-160 kDa (ITGAV) and 90-120 kDa (ITGB6) based on Bis-Tris PAGE result.
> 95% as determined by Bis-Tris PAGE
> 95% as determined by HPLC
Less than 1EU per μg by the LAL method.
Lyophilized from 0.22 μm filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
-20 to -80°C for 12 months as supplied from date of receipt.
-80°C for 3 months after reconstitution.
Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
ITGAV&ITGB6 is a receptor for fibronectin and cytotactin. It recognizes the sequence R-G-D in its ligands. Internalisation of integrin alpha-V/beta-6 via clathrin-mediated endocytosis promotes carcinoma cell invasion. ITGAV&ITGB6 acts as a receptor for fibrillin-1 (FBN1) and mediates R-G-D-dependent cell adhesion to FBN1.
αVβ6; Integrin alpha V beta 6; ITGAV&ITGB6;Integrin alpha V β 6
(1) Li J, Xu YH, Lu Y, Ma XP, Chen P, Luo SW, Jia ZG, Liu Y, Guo Y. Identifying differentially expressed genes and small molecule drugs for prostate cancer by a bioinformatics strategy. Asian Pac J Cancer Prev. 2013;14(9):5281-6. doi: 10.7314/apjcp.2013.14.9.5281. PMID: 24175814.
ITG-HM1V6-100μg / 询价
ITG-HM1V6-500μg / 询价
ITG-HM1V6-500μgx2 / 询价
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