TG3-HM00M-100μg / 询价
TG3-HM00M-500μg / 询价
TG3-HM00M-500μgx2 / 询价
Human Mature TGF beta 3 Protein
Recombinant Human Mature TGF beta 3 Protein is expressed from HEK293 without tag. It contains Ala301-Ser412.[Accession | P10600-1]
The protein has a predicted MW of 12.7 kDa. Due to glycosylation, the protein migrates to 13-15 kDa based on Tris-Bis PAGE result.
Less than 1EU per μg by the LAL method.
> 95% as determined by Tris-Bis PAGE
Lyophilized from 0.22μm filtered solution in 4mM HCl. Normally 8% trehalose is added as protectant before lyophilization.
Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in 4mM HCl.
-20 to -80°C for 12 months as supplied from date of receipt.
-80°C for 3-6 months after reconstitution.
2-8°C for 2-7 days after reconstitution.
Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Human Mature TGF beta 3 on Tris-Bis PAGE under reduced condition. The purity is greater than 95%.
Immobilized Human Mature TGF beta 3, No Tag at 1μg (100μl/Well) on the plate. Dose response curve for Human TGF-beta RII, hFc Tag with the EC50 of 15.3ng/ml determined by ELISA.
Measured by its ability to inhibit the IL-4-dependent proliferation of TF-1 cells. The ED50 for this effect is 10-80 pg/ml.
Transforming growth factor-beta 3 is a cytokine which is involved in cell growth regulation and differentiation, stimulation of extracellular matrix and modulation of immune responses. TGF beta 3 RNA is expressed in a diverse array of tissues including perichondrium, bone, intervertebral discs, mesenteries, pleura, heart, lung, palate, and amnion, as well as in central nervous system (CNS) structures such as the meninges, choroid plexus and the olfactory bulbs. Furthermore, in several organ systems, TGF beta 3 transcripts are expressed during periods of active morphogenesis suggesting that the protein may be an important factor for the growth and differentiation of many embryonic tissues.
TGF-beta-3; LAP; TGFB3; ARVD; ARVD1; RNHF;TGF-β-3
(1)Kuşcu NK, Laçin S, Vatansever S, Yildirim Y, Var A, Uyanik BS, Koyuncu F. Immunolocalization of transforming growth factor-beta 3 in pregnant human myometrium. Acta Obstet Gynecol Scand. 2001 Dec;80(12):1079-83. PMID: 11846702. (2)Pelton RW, Dickinson ME, Moses HL, Hogan BL. In situ hybridization analysis of TGF beta 3 RNA expression during mouse development: comparative studies with TGF beta 1 and beta 2. Development. 1990 Oct;110(2):609-20. doi: 10.1242/dev.110.2.609. PMID: 1723948.
